Hyaluronic acid as a modulator of the cytotoxic effects of cationic surfactants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10306885" target="_blank" >RIV/00216208:11110/15:10306885 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/15:10306885 RIV/00216208:11140/15:10306885 RIV/00216305:26310/15:PU115196
Result on the web
<a href="http://dx.doi.org/10.1016/j.colsurfa.2015.06.058" target="_blank" >http://dx.doi.org/10.1016/j.colsurfa.2015.06.058</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfa.2015.06.058" target="_blank" >10.1016/j.colsurfa.2015.06.058</a>
Alternative languages
Result language
angličtina
Original language name
Hyaluronic acid as a modulator of the cytotoxic effects of cationic surfactants
Original language description
CTAB (cetyltrimethylammonium bromide) and Septonex (carbethoxypendecinium bromide) are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of CTAB or Septonex with oppositely charged hyaluronic acid (HyA), based primarily on electrostatic interactions, were prepared with the aim to test potential modulation of surfactants cytotoxic effects. Complexes were tested for their cytotoxicity on human osteoblasts the cell metabolic activity was determined after 24h of treatment. Our data show that CTAB-HyA or Septonex-HyA complexes reduce (in different rate according to the used surfactant and HyA concentrations) cytotoxicity of both surfactants in all tested concentrations. In addition, a significant role of fetal bovine serum (important supplement of cell culture medium) in cell recovery under the stress conditions like CTAB or Septonex presence was observed. Taken together, HyA could be a useful modulator of CTAB
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN
0927-7757
e-ISSN
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Volume of the periodical
483
Issue of the periodical within the volume
October
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
155-161
UT code for WoS article
000362146200021
EID of the result in the Scopus database
2-s2.0-84941745599