Hyaluronic acid in complexes with surfactants: The efficient tool for reduction of the cytotoxic effect of surfactants on human cell types

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360172" target="_blank" >RIV/00216208:11110/17:10360172 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/17:10360172 RIV/00216305:26310/17:PU124165

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S014181301731317X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S014181301731317X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.05.173" target="_blank" >10.1016/j.ijbiomac.2017.05.173</a>

Result language

angličtina

Original language name

Hyaluronic acid in complexes with surfactants: The efficient tool for reduction of the cytotoxic effect of surfactants on human cell types

Original language description

tThe cationic surfactants carbethoxypendecinium bromide (Septonex) and cetyltrimethylammonium bro-mide (CTAB) are known to be harmful for certain cell types (bacteria, fungi, mammal cells, etc.). Colloidalcomplexes of these surfactants with negatively-charged hyaluronic acid (HyA) were prepared for poten-tial drug and/or universal delivery applications. The complexes were tested for their cytotoxic effect ondifferent human cell types - osteoblasts, keratinocytes and fibroblasts. Both the CTAB-HyA and Septonex-HyA complexes were found to reduce the cytotoxicity induced by surfactants alone concerning all thetested concentrations. Moreover, we suggested the limits of HyA protection provided by the surfactant-HyA complexes, e.g. the importance of the amount of HyA applied. We also determined the specificsensitivity of different cell types to surfactant treatment. Keratinocytes were more sensitive to CTAB,while osteoblasts and fibroblasts were more sensitive to Septonex. Moreover, it was indirectly shownthat CTAB combines lethal toxicity with cell metabolism induction, while Septonex predominantly causeslethal toxicity concerning fibroblasts. This comprehensive study of the effect of surfactant-HyA com-plexes on various human cell types revealed that HyA represents a useful CTAB or Septonex cytotoxiceffect modulator at diverse levels. Potential applications for these complexes include drug and/or nucleicacid delivery systems, diagnostic dye carriers and cosmetics production.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

—

Volume of the periodical

103

Issue of the periodical within the volume

6

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

1276-1284

UT code for WoS article

000408286400143

EID of the result in the Scopus database

2-s2.0-85020248482