Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU110567" target="_blank" >RIV/00216305:26310/14:PU110567 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Hyaluronic Acid, a Useful Tool for Modulation of Cytotoxic Effects of Cationic Surfactants
Original language description
CTAB and Septonex are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of CTAB or Septonex with oppositely charged hyaluronic acid were prepared primarily by their electrostatic interactions with the aim of their potential application in drug delivery. Hyaluronic acid seems to be promising biomaterial of near future due to its broad range of biological functions - combination of its biocompatibility and biodegradability properties and its susceptibility of chemical modifications. Hyaluronic acid can serve as a biocompatible carrier of a delivery system in which the surfactant serves as a solubilizer for hydrophobic active substance (drug). Our data show, that hyaluronic acid complexes with CTAB or Septonex reduce cytotoxicity of both antiseptics in all concentrations tested.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LD12068" target="_blank" >LD12068: Preparation of hyaluronan-micellar-aggregate colloids for nanomedical applications and characterization of their properties</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů