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IgA Nephropathy and Related Diseases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10321867" target="_blank" >RIV/00216208:11110/15:10321867 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15110/15:33157358

  • Result on the web

    <a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00105-1" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-415847-4.00105-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00105-1" target="_blank" >10.1016/B978-0-12-415847-4.00105-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    IgA Nephropathy and Related Diseases

  • Original language description

    IgA nephropathy, the most common glomerulonephritis worldwide and an important cause of renal failure, is an autoimmune glomerulonephritis wherein immune complexes consisting of IgA1 with galactose-deficient O-glycans (autoantigen) and anti-glycan autoantibodies deposit in glomeruli. IgA nephropathy frequently manifests initially in adolescents and young adults. Macroscopic hematuria coinciding with mucosal infections of the upper respiratory tract and/or digestive system is a characteristic presentation. Accumulated data suggest a multi-hit pathogenetic pathway, in which galactose-deficient IgA1 is produced at elevated levels (hit 1) and is recognized by unique circulating autoantibodies (hit 2). This process promotes formation of nephritogenic immunecomplexes (hit 3) that deposit in the kidney, activate mesangial cells, and cause renal injury (hit 4). Mesangial cells proliferate and overproduce extracellular matrix proteins and cytokines, which may injure podocytes and induce protei

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT11081" target="_blank" >NT11081: Molecular approaches for elimination or inactivation of pathogenic circulating immune complexes in IgA nephropathy and Henoch-Schoenlein purpura.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Mucosal Immunology

  • ISBN

    978-0-12-415847-4

  • Number of pages of the result

    16

  • Pages from-to

    2023-2038

  • Number of pages of the book

    2423

  • Publisher name

    Elsevier

  • Place of publication

    Amsterdam

  • UT code for WoS chapter