IgA Nephropathy and Related Diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10321867" target="_blank" >RIV/00216208:11110/15:10321867 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/15:33157358
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00105-1" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-415847-4.00105-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00105-1" target="_blank" >10.1016/B978-0-12-415847-4.00105-1</a>
Alternative languages
Result language
angličtina
Original language name
IgA Nephropathy and Related Diseases
Original language description
IgA nephropathy, the most common glomerulonephritis worldwide and an important cause of renal failure, is an autoimmune glomerulonephritis wherein immune complexes consisting of IgA1 with galactose-deficient O-glycans (autoantigen) and anti-glycan autoantibodies deposit in glomeruli. IgA nephropathy frequently manifests initially in adolescents and young adults. Macroscopic hematuria coinciding with mucosal infections of the upper respiratory tract and/or digestive system is a characteristic presentation. Accumulated data suggest a multi-hit pathogenetic pathway, in which galactose-deficient IgA1 is produced at elevated levels (hit 1) and is recognized by unique circulating autoantibodies (hit 2). This process promotes formation of nephritogenic immunecomplexes (hit 3) that deposit in the kidney, activate mesangial cells, and cause renal injury (hit 4). Mesangial cells proliferate and overproduce extracellular matrix proteins and cytokines, which may injure podocytes and induce protei
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11081" target="_blank" >NT11081: Molecular approaches for elimination or inactivation of pathogenic circulating immune complexes in IgA nephropathy and Henoch-Schoenlein purpura.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Mucosal Immunology
ISBN
978-0-12-415847-4
Number of pages of the result
16
Pages from-to
2023-2038
Number of pages of the book
2423
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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