Absence of BRAF mutation in pheochromocytoma and paraganglioma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360729" target="_blank" >RIV/00216208:11110/17:10360729 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10360729 RIV/00064203:_____/17:10360729 RIV/00064165:_____/17:10360729
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2017_215" target="_blank" >http://dx.doi.org/10.4149/neo_2017_215</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2017_215" target="_blank" >10.4149/neo_2017_215</a>
Alternative languages
Result language
angličtina
Original language name
Absence of BRAF mutation in pheochromocytoma and paraganglioma
Original language description
Pheochromocytomas and Paragangliomas (PHEO/PARA) are rare endocrine tumors originating from the adrenal medulla. More than 20 genes are involved in the tumorigenesis of these tumors, but a substantial part of the causative genetic events remains unexplained. A recent study has reported the presence of the activating BRAF V600E mutation in PCC, suggesting a role for BRAF activation in tumor development. Other studies have not find this mutation. This study investigates the occurrence of the BRAF V600E mutation in these tumors. A cohort of 64 PHEO/PARA were screened for the BRAF V600E mutation using direct Sanger sequencing and QRT-PCR. All cases investigated displayed wild-type without V600E BRAF mutation Taken together with all previously screened tumors up to date, only 1 V600E BRAF mutation has been found among 427 PCCs. These findings imply that the V600E BRAF mutation is a rare event in PHEO/PARA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
—
Volume of the periodical
64
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
5
Pages from-to
278-282
UT code for WoS article
000402091900015
EID of the result in the Scopus database
2-s2.0-85020485684