Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10362300" target="_blank" >RIV/00216208:11110/17:10362300 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10362300
Result on the web
<a href="http://dx.doi.org/10.1007/s00228-017-2208-4" target="_blank" >http://dx.doi.org/10.1007/s00228-017-2208-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00228-017-2208-4" target="_blank" >10.1007/s00228-017-2208-4</a>
Alternative languages
Result language
angličtina
Original language name
Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report
Original language description
Valproic acid (2-propylvaleric dipropyl acetic acid, VPA), the free acid form of sodium valproate, is used as a third-line drug in the management of neonatal seizures. VPA dosing in neonates, and pharmacokinetics (PK) of VPA and other anticonvulsive drugs (AEDs) are reported in a systematic review based on 19 PK studies (7 AEDs). However, prospective randomized control studies are not performed. Therapeutic plasma concentrations of VPA (CplVPA) range from 50 to 100 mg/L (347-750 μmol/L), 5-18% correspond with a free VPA fraction. Toxic CplVPA and/or VPA-metabolites may lead to VPA-induced hyperammonemic encephalopathy and VPA-induced hepatotoxicity mainly in young infants. There are several mechanisms of VPA-induced hyperammonemia, but no data are available in neonates. However, in 50% of neonates, VPA-induced hyperammonemia results in discontinuation of therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Clinical Pharmacology
ISSN
0031-6970
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
3
Pages from-to
647-649
UT code for WoS article
000399175100017
EID of the result in the Scopus database
2-s2.0-85011662556