Ancient hepatitis B viruses from the Bronze Age to the Medieval period

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10375740" target="_blank" >RIV/00216208:11110/18:10375740 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1038/s41586-018-0097-z" target="_blank" >https://doi.org/10.1038/s41586-018-0097-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41586-018-0097-z" target="_blank" >10.1038/s41586-018-0097-z</a>

Result language

angličtina

Original language name

Ancient hepatitis B viruses from the Bronze Age to the Medieval period

Original language description

Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to between 8.6 and 20.9 thousand years ago, and we estimate a substitution rate of 8.04 x 10(-6-)1.51 x 10(-5) nucleotide substitutions per site per year. In several cases, the geographical locations of the ancient genotypes do not match present-day distributions. Genotypes that today are typical of Africa and Asia, and a subgenotype from India, are shown to have an early Eurasian presence. The geographical and temporal patterns that we observe in ancient and modern HBV genotypes are compatible with well-documented human migrations during the Bronze and Iron Ages(1,2). We provide evidence for the creation of HBV genotype A via recombination, and for a long-term association of modern HBV genotypes with humans, including the discovery of a human genotype that is now extinct. These data expose a complexity of HBV evolution that is not evident when considering modern sequences alone.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

60101 - History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

—

Volume of the periodical

557

Issue of the periodical within the volume

7705

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

418-423

UT code for WoS article

000432242000059

EID of the result in the Scopus database

2-s2.0-85047151160