Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376939" target="_blank" >RIV/00216208:11110/18:10376939 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1073/pnas.1804921115" target="_blank" >https://doi.org/10.1073/pnas.1804921115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1073/pnas.1804921115" target="_blank" >10.1073/pnas.1804921115</a>

Result language

angličtina

Original language name

Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans

Original language description

Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to similar to 70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from similar to 0.5 to similar to 6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is placed similar to 12.6 kya, and we find a substitution rate that is an order of magnitude lower than inferred previously. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to similar to 5.0-6.8 kya. This study emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

60101 - History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Proceedings of the National Academy of Sciences of the United States of America

ISSN

0027-8424

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

29

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

7557-7562

UT code for WoS article

000438892600059

EID of the result in the Scopus database

2-s2.0-85050003851