Estimation of once-daily amikacin dose in critically ill adults
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376634" target="_blank" >RIV/00216208:11110/18:10376634 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1080/1120009X.2017.1376818" target="_blank" >https://doi.org/10.1080/1120009X.2017.1376818</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/1120009X.2017.1376818" target="_blank" >10.1080/1120009X.2017.1376818</a>
Alternative languages
Result language
angličtina
Original language name
Estimation of once-daily amikacin dose in critically ill adults
Original language description
This study aimed at investigating variables affecting amikacin pharmacokinetics in order to propose optimal initial dosing in critically ill adult patients treated with once-daily amikacin regimen. Amikacin pharmacokinetics was calculated based on plasma concentrations using one compartmental analysis. Relationships between pharmacokinetic parameters and demographic/clinical data were explored in linear regression models. Simulated dose and dosing intervals were derived from body size descriptors and estimated creatinine clearances for each patient. Amikacin volume of distribution best correlated with body surface area, while amikacin clearance was best predicted by CKD-EPI creatinine clearance. Our study suggests that dose of 517 mg per m(2) of body surface area leads to amikacin levels most approaching target peak concentration. Dosing interval calculated as 228.7 x e(-3.08 x) (CKD-EPI) (creatinine clearance) ((mL s-1)) + 15.84 most closely approximated optimal dosing intervals based on individual pharmacokinetics. The dosing nomogram based on CKD-EPI creatinine clearance was designed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chemotherapy
ISSN
1120-009X
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
1
Country of publishing house
IT - ITALY
Number of pages
7
Pages from-to
37-43
UT code for WoS article
000428154600005
EID of the result in the Scopus database
2-s2.0-85030172217