Brain perfusion evaluated by regional tissue oxygenation as a possible quality indicator of ongoing cardiopulmonary resuscitation. An experimental porcine cardiac arrest study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376842" target="_blank" >RIV/00216208:11110/18:10376842 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21730/18:00327583 RIV/00064165:_____/18:10376842
Result on the web
<a href="https://doi.org/10.1177/0267659118766282" target="_blank" >https://doi.org/10.1177/0267659118766282</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0267659118766282" target="_blank" >10.1177/0267659118766282</a>
Alternative languages
Result language
angličtina
Original language name
Brain perfusion evaluated by regional tissue oxygenation as a possible quality indicator of ongoing cardiopulmonary resuscitation. An experimental porcine cardiac arrest study
Original language description
Introduction: Relationship between regional tissue oxygenation (rSO(2)) and microcirculatory changes during cardiac arrest (CA) are still unclear. Therefore, we designed an experimental study to correlate rSO(2), microcirculation and systemic hemodynamic parameters in a porcine model of CA. Methods: Ventricular fibrillation was induced in 24 female pigs (503kg) and left for three minutes untreated followed by five minutes of mechanical CPR. Regional and peripheral saturations were assessed by near-infrared spectroscopy, sublingual microcirculation by Sidestream Dark Field technology and continuous hemodynamic parameters, including systemic blood pressure (MAP) and carotid blood flow (CF), during baseline, CA and CPR periods. The Wilcoxon Signed-Rank test, the Friedman test and the partial correlation method were used to compare these parameters. Results: Brain and peripheral rSO(2) showed a gradual decrease during CA and only an increase of brain rSO(2) during mechanical CPR (34.5 to 42.5; p=0.0001), reflected by a rapid decrease of microcirculatory and hemodynamic parameters during CA and a slight increase during CPR. Peripheral rSO(2) was not changed significantly during CPR (38 to 38.5; p=0.09). We only found a moderate correlation of cerebral/peripheral rSO(2) to microcirculatory parameters (PVD: r=0.53/0.46; PPV: r=0.6/0.5 and MFI: r=0.64/0.52) and hemodynamic parameters (MAP: r=0.64/0.71 and CF: 0.71/0.67). Conclusions: Our experimental study confirmed that monitoring brain and peripheral rSO(2) is an easy-to-use method, well reflecting the hemodynamics during CA. However, only brain rSO(2) reflects the CPR efforts and might be used as a potential quality indicator for CPR.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Perfusion
ISSN
0267-6591
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
Supplement 1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
65-70
UT code for WoS article
000432998400009
EID of the result in the Scopus database
2-s2.0-85047437605