Cardiotoxicity of beta-mimetic catecholamines during ontogenetic development - possible risks of antenatal therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10377124" target="_blank" >RIV/00216208:11110/18:10377124 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/18:00492488 RIV/00064165:_____/18:10377124

Result on the web

<a href="https://doi.org/10.1139/cjpp-2017-0774" target="_blank" >https://doi.org/10.1139/cjpp-2017-0774</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1139/cjpp-2017-0774" target="_blank" >10.1139/cjpp-2017-0774</a>

Result language

angličtina

Original language name

Cardiotoxicity of beta-mimetic catecholamines during ontogenetic development - possible risks of antenatal therapy

Original language description

Catecholamines are involved in the regulation of a wide variety of vital functions. The beta-adrenergic receptor (beta-AR) adenylyl cyclase system has been identified early in embryogenesis before the heart has received adrenergic innervation. The structure of beta-receptors in the immature myocardium is similar to that in adults; there are, however, significant quantitative developmental changes in the inotropic and chronotropic responsiveness. Information on the toxic effect of the beta-AR agonists in the immature heart is surprisingly scarce, even though these agents are used in clinical practice both during pregnancy and in early postnatal development. Large doses of beta-AR agonists induce malformations of the cardiovascular system; the type of change depends upon the time at which the beta-AR agonist was administered during embryogenesis. During postnatal ontogeny, the cardiotoxicity of beta-AR agonists increased from birth to adulthood. It seems likely that despite interspecies differences, developmental changes in the cardiac sensitivity to beta-AR agonists may exist in all mammals, depending on the degree of maturation of the system involved in beta-adrenergic signaling. All the existing data draw attention to the possible harmful consequences of the clinical use of beta-AR agonists during early phases of cardiac development. Late effects of the early disturbances of the cardiac muscle cannot be excluded.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Canadian Journal of Physiology and Pharmacology

ISSN

0008-4212

e-ISSN

—

Volume of the periodical

96

Issue of the periodical within the volume

7

Country of publishing house

CA - CANADA

Number of pages

8

Pages from-to

639-646

UT code for WoS article

000438114100001

EID of the result in the Scopus database

2-s2.0-85049825402