Severe suicidal self-poisoning with massive dose of potassium ferricyanide(III): hyperkalemia but not free cyanide may cause death
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378274" target="_blank" >RIV/00216208:11110/18:10378274 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/18:00492509 RIV/00064165:_____/18:10378274
Result on the web
<a href="https://doi.org/10.1007/s00706-018-2231-x" target="_blank" >https://doi.org/10.1007/s00706-018-2231-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-018-2231-x" target="_blank" >10.1007/s00706-018-2231-x</a>
Alternative languages
Result language
angličtina
Original language name
Severe suicidal self-poisoning with massive dose of potassium ferricyanide(III): hyperkalemia but not free cyanide may cause death
Original language description
Potassium ferricyanide(III), K-3[Fe(CN)(6)], has a widespread use in blueprint drawing, photography, chemical industry, and metallurgy. In mice, the oral lethal dose 50 (LD50) is 1600 mg kg(-1). We report the case of a suicide attempt in a 37-year-old male by intentional ingestion of 80 g of potassium ferricyanide(III) dissolved in water. The estimated ingested dose was 770 mg kg(-1). The patient reported vertigo as the first sign of poisoning and six episodes of diarrhea with dark-colored stool 2 h after ingestion. The patient was transported by ambulance to the intensive care unit 8 h after ingestion. He was conscious and spontaneously ventilating, with a Glasgow Coma Scale (GCS) score of 15. On ECG performed at admission, tall "tented" T waves in V3-V6 and progressive flattering of P waves were registered. Serum concentrations of potassium of 7.2 mmol dm(-3), urea of 7.1 mmol dm(-3), and creatinine of 162 A mu mol dm(-3) indicated development of acute renal failure. Despite the administration of intravenous insulin and 10% glucose infusion during the first hours after admission, there was a further elevation of serum potassium to 7.4 mmol dm(-3) suggesting acute renal failure. For this reason, intermittent hemodialysis was performed [duration 200 min, blood flow rate 147 cm(3) min(-1), online clearance monitoring (OCM) clearance rate 100 cm(3) min(-1), and substitution fluid volume 5.8 dm(3)]. The condition of the patient stabilized and he was discharged from hospital on the fourth day after admission. This case report demonstrates the risks of life-threatening hyperkalemia and acute renal failure as complications of massive ingestion of potassium ferricyanide(III).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte für Chemie - Chemical Monthly
ISSN
0026-9247
e-ISSN
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Volume of the periodical
149
Issue of the periodical within the volume
9
Country of publishing house
AT - AUSTRIA
Number of pages
5
Pages from-to
1647-1651
UT code for WoS article
000442501400021
EID of the result in the Scopus database
2-s2.0-85051624890