Vancomycin pharmacokinetics during high-volume continuous venovenous hemofiltration in critically ill septic patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0103867" target="_blank" >RIV/00843989:_____/14:E0103867 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/14:A15015QB RIV/61989592:15110/14:33140997
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2012.092" target="_blank" >http://dx.doi.org/10.5507/bp.2012.092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2012.092" target="_blank" >10.5507/bp.2012.092</a>

Result language
angličtina
Original language name
Vancomycin pharmacokinetics during high-volume continuous venovenous hemofiltration in critically ill septic patients
Original language description
Aims: To assess the influence of continuous venovenous hemofiltration (CVVH) at a filtration rate of 45 mL/kg/h on vancomycin pharmacokinetics in critically ill septic patients with acute kidney injury (AKI). Methods: Seventeen adult septic patients withacute kidney injury treated with CVVH and vancomycin were included. All patients received first dose of 1.0 g intravenously followed by 1.0 g/12 h if not adjusted. In sixteen patients vancomycin was introduced on the day of the start of CRRT therapy. Blood samples and ultrafiltrates were obtained before and 0.5, 1, 6 and 12 h after vancomycin administration. Results: On the first day, the median total vancomycin clearance (Cltot) was 0.89 mL/min/kg (range 0.31 - 2.16). CRRT clearance accounted for around 50-60% of the total clearance of vancomycin found in a population with normal renal function (0.97 mL/min/kg). Vancomycin serum concentrations after the first dose were below the required target of 10 mg/L as early as 6 h in 10 patient
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—

Project
<a href="/en/project/NS10309" target="_blank" >NS10309: Changes of pharmacokinetics of vancomycin and gentamicin in continual and intermittent elimination methods in sepsis and acute kidney insufficiency, the use of a predictive pharmacokinetic model in dosing of selected antibiotics.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)