Gentamicin pharmacokinetics during continuous venovenous hemofiltration in critically ill septic patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102439" target="_blank" >RIV/00843989:_____/12:00102439 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/12:A1301487 RIV/61989592:15110/12:33138907
Result on the web
<a href="http://dx.doi.org/10.1179/1120009X12Z.0000000006" target="_blank" >http://dx.doi.org/10.1179/1120009X12Z.0000000006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1179/1120009X12Z.0000000006" target="_blank" >10.1179/1120009X12Z.0000000006</a>

Result language
angličtina
Original language name
Gentamicin pharmacokinetics during continuous venovenous hemofiltration in critically ill septic patients
Original language description
Objective: Current dosing recommendations for administration of gentamicin to septic patients with acute kidney injury (AKI) on continuous venovenous hemofiltration (CVVH) at a filtration rate of 45 ml/kg/h are missing. Aim: To describe gentamicin pharmacokinetics and to find an optimal dosing regimen in patients on CVVH. Methods: Seven adult patients were included. Patients received loading dose of 240 mg followed by application of maintenance dose every 24 hours. Maintenance dose was adjusted according to gentamicin C-max/MIC ratio and drug levels simulation using a pharmacokinetic programme. Results: Median total clearance (0.59-0.79 ml/min/kg) was similar to patients with normal renal function; median volume of distribution was higher than observedin non-septic patients (about 0.5 l/kg versus 0.25 l/kg). Patients with diuresis required an increase of gentamicin dose to reach C-max/MIC ratio. Conclusion: Septic patients with AKI on CVVH (45 ml/kg/h) require a loading dose of 240 mg
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/NS10309" target="_blank" >NS10309: Changes of pharmacokinetics of vancomycin and gentamicin in continual and intermittent elimination methods in sepsis and acute kidney insufficiency, the use of a predictive pharmacokinetic model in dosing of selected antibiotics.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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