Avidity of anti-phospholipid antibodies in relation to their levels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10413865" target="_blank" >RIV/00216208:11110/20:10413865 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/20:10413865

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZvH4~HIRGS" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZvH4~HIRGS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/ceji.2020.97901" target="_blank" >10.5114/ceji.2020.97901</a>

Result language

angličtina

Original language name

Avidity of anti-phospholipid antibodies in relation to their levels

Original language description

Introduction: The heterogeneity of anti-phospholipid antibodies can be manifested not only in different antigenic specificities, but also in their avidities. The aim of the study was to investigate the relationship between anti-cardiolipin antibody (aCL) IgG avidities and levels within the range of their titres, from very low to high ones. Material and methods: We analyzed 78 serum samples from 60 patients by ELISA with chaotropic agents, using urea concentration of 6 and 8 mol/l and single diluted serum samples. The changes of aCL levels and avidities were explored during a long-term follow-up in 14 patients. Results: The avidities of aCLs did not differ in the groups of patients classified according to aCL levels. The higher avidity antibodies predominated in our patients and the fluctuation of avidities in the longitudinal follow-up did not show significant differences. No relationship between aCL levels and their avidities was found. Conclusions: aCL avidities seem to have no relationship with aCL levels and high-avidity aCLs; the potentially deleterious effects might be present also in patients with low and extremely low aCL levels. Avidity of aCLs belongs to stable characteristics with insignificant changes in time.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central-European Journal of Immunology

ISSN

1426-3912

e-ISSN

—

Volume of the periodical

45

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

136-143

UT code for WoS article

000559731700003

EID of the result in the Scopus database

2-s2.0-85090571551