Magnetic nanoparticles of Ga-substituted epsilon-Fe2O3 for biomedical applications: Magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10414844" target="_blank" >RIV/00216208:11110/20:10414844 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/20:10414844 RIV/00216208:11320/20:10414844 RIV/00216275:25310/20:39916530

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ARdz-m28RU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ARdz-m28RU</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.36926" target="_blank" >10.1002/jbm.a.36926</a>

Result language

angličtina

Original language name

Magnetic nanoparticles of Ga-substituted epsilon-Fe2O3 for biomedical applications: Magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Original language description

Magnetic nanoparticles of epsilon-Fe1.76Ga0.24O3 with the volume-weighted mean size of 17 nm were prepared by thermal treatment of a mesoporous silica template impregnated with metal nitrates and were coated with silica shell of four different thicknesses in the range 6-24 nm. The bare particles exhibited higher magnetization than the undoped compound, 22.4 Am-2 kg(-1) at 300 K, and were characterized by blocked state with the coercivity of 1.2 T at 300 K, being thus the very opposite of superparamagnetic iron oxides. The relaxometric study of the silica-coated samples at 0.47 T revealed promising properties for MRI, specifically, transverse relaxivity of 89-168 s(-1) mmol(f.u.)(-1) L depending on the shell thickness was observed. We investigated the effects of the silica-coated nanoparticles on human A549 and MCF-7 cells. Cell viability, proliferation, cell cycle distribution, and the arrangement of actin cytoskeleton were assessed, as well as formation and maturation of focal adhesions. Our study revealed that high concentrations of silica-coated particles with larger shell thicknesses of 16-24 nm interfere with the actin cytoskeletal networks, inducing thus morphological changes. Consequently, the focal adhesion areas were significantly decreased, resulting in impaired cell adhesion.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA18-13323S" target="_blank" >GA18-13323S: Composite nanoparticles with magnetically and light activated release of biologically active compounds</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biomedical Materials Research - Part A

ISSN

1549-3296

e-ISSN

—

Volume of the periodical

108

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

1563-1578

UT code for WoS article

000521206500001

EID of the result in the Scopus database

2-s2.0-85082193141