Magnetic nanoparticles of Ga-substituted ε-Fe2O3 for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00532459" target="_blank" >RIV/68378271:_____/20:00532459 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/jbm.a.36926" target="_blank" >https://doi.org/10.1002/jbm.a.36926</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.36926" target="_blank" >10.1002/jbm.a.36926</a>

Result language

angličtina

Original language name

Magnetic nanoparticles of Ga-substituted ε-Fe2O3 for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

Original language description

Magnetic nanoparticles of epsilon-Fe1.76Ga0.24O3 with the volume-weighted mean size of 17 nm were prepared by thermal treatment of a mesoporous silica template impregnated with metal nitrates and were coated with silica shell of four different thicknesses in the range 6-24 nm. The bare particles exhibited higher magnetization than the undoped compound, 22.4 Am-2 kg-1 at 300 K, and were characterized by blocked state with the coercivity of 1.2 T at 300 K. The relaxometric study of the silica-coated samples at 0.47 T revealed promising properties for MRI, specifically, transverse relaxivity of 89-168 s-1mmol(f)-1L depending on the shell thickness was observed. We investigated the effects of the silica-coated nanoparticles on human A549 and MCF-7 cells. Cell viability, proliferation, cell cycle distribution, and the arrangement of actin cytoskeleton were assessed, as well as formation and maturation of focal adhesions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

21001 - Nano-materials (production and properties)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biomedical Materials Research. Part A

ISSN

1549-3296

e-ISSN

—

Volume of the periodical

108

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

1563-1578

UT code for WoS article

000521206500001

EID of the result in the Scopus database

2-s2.0-85082193141