Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10416107" target="_blank" >RIV/00216208:11110/20:10416107 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00116718 RIV/00216208:11140/20:10416107 RIV/65269705:_____/20:00073262 RIV/00669806:_____/20:10416107 RIV/00023001:_____/20:00080453

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=o5pik7FSNr" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=o5pik7FSNr</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00038-020-01496-y" target="_blank" >10.1007/s00038-020-01496-y</a>

Result language

angličtina

Original language name

Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics

Original language description

Objectives The MOSAIC study gathered data on chronic hepatitis C virus (HCV) infection and its treatment in various countries worldwide. Here we summarise patient and HCV characteristics in the Czech Republic and Slovakia. Methods MOSAIC was an observational study that included patients with chronic HCV infection untreated at the time of enrolment. Study collected and descriptively analysed patient demographics, disease stage and viral characteristics. Data were collected between February 2014 to October 2014. Results Among 220 patients enrolled, 51.4% were treatment-naıve. The most prevalent HCV genotype was G1 (78.4%), followed by G3 (19.7%). Higher prevalence of G1 was found in treatment-experienced patients (94.3%) compared to treatment-naıve (63.4%). Most participants (67.7%) presented viral RNA load of C 800,000 IU/mL. Liver cirrhosis was reported in 24.5% of patients. Higher HCV RNA load and duration of HCV infection correlated with the degree of liver fibrosis. Anti-HCV interferon-based treatments were initiated in 88.2% of participants. Conclusions The study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Public Health

ISSN

1661-8556

e-ISSN

—

Volume of the periodical

65

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1723-1735

UT code for WoS article

000576627700002

EID of the result in the Scopus database

2-s2.0-85092385126