Can gram-negative-like biomarker values in Streptococcus pyogenes sepsis negatively influence right choice of initial antibiotic therapy?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10417140" target="_blank" >RIV/00216208:11110/20:10417140 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/20:10417140

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IDZ2GIk042" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IDZ2GIk042</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Can gram-negative-like biomarker values in Streptococcus pyogenes sepsis negatively influence right choice of initial antibiotic therapy?

Original language description

introduction: Biomarkers of sepsis are used to facilitate the diagnosis of sepsis and antibiotic stewardship. Gram-negative sepsis has been reported to have a distinct pattern of markedly increased procalcitonin vs. C-reactive protein compared to patients with Gram-positive sepsis. However, selected infective agents may not follow this pattern, possibly leading to inappropriate choice of ATB therapy, (namely in Streptococcus pyogenes infection). methods: We retrospectively evaluated charts of septic patients infected by S. pyogenes, Escherichia coli or with Staphylococcus aureus sepsis, their biomarker pattern, appropriateness of the initial ATB therapy, a nd outcome. Biomarker values were compared using Kruskal-Wallis test followed by Dunn Post-Hoc tests and as a threshold was used p &lt; 0.05. results: Procalcitonin levels were higher in S. pyogenes sepsis (12.51 ng/ml, IQR: 6.26-48.38 ng/ml) vs E. coli sepsis (4.30 ng/ml, IQR: 1.50-10.00 ng/ml, p &lt; 0.001) and vs S. aureus sepsis (0.75 ng/ml, QR: 0.34-1.62 ng/ml, p &lt; 0.001). Neutrophil to lymphocyte ratio followed the same pattern as prokalcitonin. Initial appropriate ATB therapy in S. pyogenes cohort was 11.29% compared to 99.3% and 100% in S. aureus and E. coli group, respectively. conclusion: Contrasting previous reports, the highest procalcitonin values were observed in the S. pyogenes group rather than in gram-negative sepsis. This has contributed to an inappropriate initial ATB therapy and, we believed, resulted in higher mortality in this group. Therefore, we recommend a re-evaluation of current procalcitonin values in order to improve both survival rate as well as patient&apos;s quality of life in general.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epidemiologie, mikrobiologie, imunologie

ISSN

1210-7913

e-ISSN

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Volume of the periodical

69

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

128-133

UT code for WoS article

000584474500004

EID of the result in the Scopus database

2-s2.0-85094126851