Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10428118" target="_blank" >RIV/00216208:11110/21:10428118 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/21:10428118
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=k90aldpCdZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=k90aldpCdZ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22084182" target="_blank" >10.3390/ijms22084182</a>

Result language
angličtina
Original language name
Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?
Original language description
Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. Although the use of genetic risk scores further improves CVD prediction, the significance is not unambiguous, and some subjects at risk remain undetected. Further research directions should focus on the "second level" of genetic information, namely, regulatory molecules (miRNAs) and epigenetic changes, predominantly DNA methylation and gene-environment interactions.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
<a href="/en/project/NV17-28882A" target="_blank" >NV17-28882A: Genetic plymorphisms, MicroRNAs and bioindicators of activity: interrelations in the diagnostics and therapy of severe familial hypercholesterolemia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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