Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10432543" target="_blank" >RIV/00216208:11110/21:10432543 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/21:10432543

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=6W0ZEcam6-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=6W0ZEcam6-</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/ejhpharm-2019-002013" target="_blank" >10.1136/ejhpharm-2019-002013</a>

Result language

angličtina

Original language name

Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function

Original language description

Objectives: Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosing nomogram for initial treatment. Methods: Vancomycin pharmacokinetics was calculated in a two-compartmental model based on therapeutic drug monitoring data. A linear regression model was used to explore the relationship between vancomycin elimination half-life and glomerular filtration rate estimated according the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Results: In the whole study population (n=66), vancomycin volume of distribution, clearance and half-life median (IQR) values were 0.69 (0.58-0.87) L/kg, 0.031 (0.022-0.050) L/h/kg and 14.4 (9.5-25.2) hours, respectively. Vancomycin half-life was associated with glomerular filtration rate (r2=0.4126, p&lt;0.0001) according to the formula: t1/2 (h) = -0.247xeGFRCKD-EPI (mL/min/1.73 m2)+32.89. This relationship was used to construct a dosing nomogram. Conclusions: We propose an easy-to-use dosing nomogram for vancomycin therapy initiation that allows individualisation of the dosing interval with respect to the administered dose size and functional renal status.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Hospital Pharmacy

ISSN

2047-9956

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

276-279

UT code for WoS article

000691003100008

EID of the result in the Scopus database

2-s2.0-85070687535