Worse Outcomes of Early Targeted Ibuprofen Treatment Compared to Expectant Management of Patent Ductus Arteriosus in Extremely Premature Infants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10433880" target="_blank" >RIV/00216208:11110/21:10433880 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/21:10433880

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8zz_1BIeS8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8zz_1BIeS8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4103/jcn.jcn_73_21" target="_blank" >10.4103/jcn.jcn_73_21</a>

Result language

angličtina

Original language name

Worse Outcomes of Early Targeted Ibuprofen Treatment Compared to Expectant Management of Patent Ductus Arteriosus in Extremely Premature Infants

Original language description

Aims: The aim of the study is to evaluate two different patent ductus arteriosus (PDA) management approaches and their impact on neonatal mortality and/or bronchopulmonary dysplasia (BPD) and 2-year outcomes. Subjects and Methods: For two consecutive periods, data on early mortality and morbidity were obtained retrospectively, while long-term morbidity data in children born before 28 weeks of gestation were collected prospectively. In the early targeted treatment period (TTP), ibuprofen was early indicated on patients with high clinical risk and PDA diameter of more than two millimeters in the first 3 days. In the expectant treatment period (EXP), the expectant approach was used. Results: A total of 201 eligible infants were screened. Of these, 99 were managed in the TTP and 102 in the EXP. From 99 infants in the TTP, 24 patients were treated early and 17 later. From 102 infants in the EXP, 17 infants with symptomatic PDA were treated. Severe BPD and/or death were more frequent in the TTP as compared to EXP (28 and 16 infants, respectively; P = 0.007; odds ratio = 2.12; confidence interval = 1.06-4.23; c = 0.216). Moreover, infants who underwent the expectant approach did not need further cardiological interventions after discharge. Conclusions: Early targeted treatment of large PDAs was associated with an increased risk of severe BPD and/or death. We must pay attention to the side effects of early ibuprofen treatment because these may outweigh the benefits of ductus closure, especially in the vulnerable population of extremely preterm infants. &lt;/p&gt;

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30200 - Clinical medicine

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Neonatology

ISSN

2249-4847

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

IN - INDIA

Number of pages

7

Pages from-to

209-215

UT code for WoS article

000702262300001

EID of the result in the Scopus database

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