Spontaneous Closure of Patent Ductus Arteriosus in Infants <= 1500 g
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913435" target="_blank" >RIV/00216208:11120/17:43913435 - isvavai.cz</a>
Alternative codes found
RIV/00023698:_____/17:N0000022
Result on the web
<a href="http://dx.doi.org/10.1542/peds.2016-4258" target="_blank" >http://dx.doi.org/10.1542/peds.2016-4258</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1542/peds.2016-4258" target="_blank" >10.1542/peds.2016-4258</a>
Alternative languages
Result language
angličtina
Original language name
Spontaneous Closure of Patent Ductus Arteriosus in Infants <= 1500 g
Original language description
OBJECTIVES: Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical intervention. METHODS: A retrospective cohort study conducted in 2 European level-3 neonatal units. RESULTS: A total of 368 VLBW infants were born within the study period. Two hundred and ninety-seven infants were free of congenital malformations or heart defects and survived to hospital discharge. Out of those, 280 infants received truly conservative PDA management. In 237 (85%) of nontreated infants, the PDA closed before hospital discharge. The Kaplan-Meier model was used to document the incidence proportion of PDA closure over time for different gestational age groups. The median time to ductal closure was 71, 13, 8, and 6 days in <26+0, 26+0 to 27+6, 28+0 to 29+6, and >=30 weeks, respectively. For different birth weight groups, the median was 48, 22, 9, and 8 days in infants weighing <750, 750 to 999, 1000 to 1249, and 1250 to 1500 g, respectively. No statistically significant relationship was found between PDA closure before hospital discharge and neonatal morbidities. CONCLUSIONS: The likelihood of PDA spontaneous closure in VLBW infants is extremely high. We provide in our findings a platform for future placebo-controlled trials focused on the smallest and youngest infants.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatrics
ISSN
0031-4005
e-ISSN
—
Volume of the periodical
140
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"Article e20164258"
UT code for WoS article
000406659900019
EID of the result in the Scopus database
2-s2.0-85026671944