A conservative treatment of patent ductus arteriosus in very low birth weight infants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43912817" target="_blank" >RIV/00216208:11120/17:43912817 - isvavai.cz</a>

Alternative codes found

RIV/00023698:_____/17:N0000027

Result on the web

<a href="http://dx.doi.org/10.1016/j.earlhumdev.2016.12.008" target="_blank" >http://dx.doi.org/10.1016/j.earlhumdev.2016.12.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.earlhumdev.2016.12.008" target="_blank" >10.1016/j.earlhumdev.2016.12.008</a>

Result language

angličtina

Original language name

A conservative treatment of patent ductus arteriosus in very low birth weight infants

Original language description

Background Treatment of the patent ductus arteriosus (PDA) in the preterm infant remains contentious. There are numerous options of the PDA management from early targeted treatment, late (symptomatic) treatment to no treatment at all. Aims To evaluate a three different PDA management approaches in very low birth weight (VLBW) infants. Study design A retrospective observational time series study of three cohorts of VLBW infants born between 2004 and 2011. Subjects Infants in Symptomatic Treatment Group (STG) were echocardiographically evaluated when clinical signs suggestive of a PDA were present and treated if a haemodynamically significant PDA was confirmed. Early Targeted Group (ETG) underwent echocardiography within the first 48 h and infants received ibuprofen if a large PDA was present. Conservative Treatment Group (CTG) was screened by echocardiography on day seven of life; patients with PDA were managed with increased positive end expiratory pressure and fluid restriction as a first line intervention. Outcomes The primary outcome was medical and surgical treatment in the three time periods. Secondary outcomes included mortality, severe periventricular and intraventricular haemorrhage, respiratory distress syndrome and chronic lung disease. Results There were 138 infants diagnosed with PDA; 52 infants in STG, 52 infants in ETG and 34 infants in CTG. Ibuprofen therapy and ligation were less frequent in CTG. There was significantly decreased incidence of chronic lung disease in CTG compared to STG (18% vs. 51%; p = 0.003) and to ETG (18% vs. 46%; p = 0.02). There was no difference in the other short term outcomes. Conclusion Conservative treatment of persistent ductus arteriosus in VLBW infants is a feasible option and future randomized trials of conservative management are warranted.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Early Human Development

ISSN

0378-3782

e-ISSN

—

Volume of the periodical

104

Issue of the periodical within the volume

January

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

45-49

UT code for WoS article

000394201100009

EID of the result in the Scopus database

2-s2.0-85007545142