Effect of TiO2 Nanoparticles Defect Structure on their ROS Scavenging Ability

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10496511" target="_blank" >RIV/00216208:11110/24:10496511 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1109/NAP62956.2024.10739734" target="_blank" >https://doi.org/10.1109/NAP62956.2024.10739734</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/NAP62956.2024.10739734" target="_blank" >10.1109/NAP62956.2024.10739734</a>

Result language

angličtina

Original language name

Effect of TiO2 Nanoparticles Defect Structure on their ROS Scavenging Ability

Original language description

Titanium dioxide nanoparticles (TiO2 NPs) have attracted significant interest for their ability to modulate reactive oxygen species (ROS) levels within cells. These nanoparticles have shown promise in drug delivery, sonodynamic, photodynamic, photothermal, and ionizing radiation-based anti-cancer therapies, as well as antimicrobial and antioxidant applications. In this study, we analyzed the effects of TiO2 NP defect structures-specifically the presence of stoichiometric (Ti4+) and non-stoichiometric (Ti-3. and Ti-2.) titanium ions within the crystal lattice-and the aggregation state of TiO2 NPs on their ROS scavenging capabilities in both cell-free conditions and H2O2-treated L929 cells. Two types of TiO2 NPs with varying concentrations of Ti-3. and Ti-2. ions were synthesized and characterized using XRD, TEM, SAXS, and XPS techniques. The antioxidant properties of these TiO2 NPs were assessed through chemiluminescence and optical spectroscopy using ROS sensors. Results from chemiluminescence and total antioxidant capacity assays indicated that the synthesized TiO2 NPs possess radical scavenging abilities, with TiO2 NPs(1), containing a higher amount of non- stoichiometric titanium ions, demonstrating a stronger effect. Concentrations of up to 40 mg/L of TiO2 NPs showed no impact on L929 cell viability or cell death. Moreover, TiO2 NPs(1) exhibited a tendency to reduce H2O2-induced oxidative stress in L929 cells, while TiO2 NPs(2) had the opposite effect, likely due to their propensity for aggregation in the cell medium. Our findings suggest that the synthesized TiO2 NPs have potential as agents for modulating intracellular ROS levels at concentrations that do not compromise cell viability.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

30100 - Basic medicine

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

2024 IEEE 14th International Conference Nanomaterials: Applications &amp; Properties (NAP)

ISBN

979-8-3503-8013-2

ISSN

—

e-ISSN

—

Number of pages

5

Pages from-to

1-5

Publisher name

IEEE

Place of publication

New York

Event location

Riga

Event date

Sep 8, 2024

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

001424467800061