Prenatal morphine exposure differentially alters learning and memory in male and female rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A00003615" target="_blank" >RIV/00216208:11120/01:00003615 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/S0031-9384(01)00469-3" target="_blank" >http://dx.doi.org/10.1016/S0031-9384(01)00469-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0031-9384(01)00469-3" target="_blank" >10.1016/S0031-9384(01)00469-3</a>

Result language
angličtina
Original language name
Prenatal morphine exposure differentially alters learning and memory in male and female rats
Original language description
The present study tested the hypothesis that exposure to morphine on prenatal days 11-18 impairs performance on tasks requiring learning and memory in adult male and female rats. In Experiment 1, a symmetrical maze was used to measure learning. In Experiment 2, an eight-arm radial maze was used to assess working spatial memory. The results of Experiment 1 demonstrated that prenatal morphine exposure reduces the time needed to complete the trials, but does not affect the accuracy of performance in male rats. In contrast, prenatal drug treatment had no effects on either the time or the accuracy of performance in female rats. In Experiment 2, both male and female morphine exposed rats needed more time to complete regular trials (no delay) than controls; however, morphine exposure in male rats did not affect performance on tasks requiring memory, measured with delay trials, but hindered it in ovariohysterectomized (OVX) female rats.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
<a href="/en/project/IZ3613" target="_blank" >IZ3613: Effects of repeated seizures and long-term antiepileptic therapy on brain morphology and function</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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