Effects of D2-dopamine and α-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00002993" target="_blank" >RIV/00216208:11120/02:00002993 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/s0165-5728(02)00211-4" target="_blank" >http://dx.doi.org/10.1016/s0165-5728(02)00211-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/s0165-5728(02)00211-4" target="_blank" >10.1016/s0165-5728(02)00211-4</a>

Result language

angličtina

Original language name

Effects of D2-dopamine and α-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice

Original language description

The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

<a href="/en/project/GA310%2F98%2F0347" target="_blank" >GA310/98/0347: The dopamine and prolactin role during tumor progression and immunomodulatory effect of dopaminergic ergot alkaloids.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuroimmunology

ISSN

0165-5728

e-ISSN

—

Volume of the periodical

130

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

55-65

UT code for WoS article

000178329200006

EID of the result in the Scopus database

2-s2.0-0036709023