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TFIIH plays an essential role in RNA polymerase I transcription

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003591" target="_blank" >RIV/00216208:11120/02:00003591 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/S0092-8674(02)00729-8" target="_blank" >http://dx.doi.org/10.1016/S0092-8674(02)00729-8</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/S0092-8674(02)00729-8" target="_blank" >10.1016/S0092-8674(02)00729-8</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    TFIIH plays an essential role in RNA polymerase I transcription

  • Original language description

    TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNAsynthesis is impaired in TFIIH ts strains. In a mouse, part of cellular TFIIH is localized within the nucleolus and is associated with subpopulations of both RNA polymerase I and the basal factor TIF-IB. Transcription systems lacking TFIIH are inactiveand exogenous TFIIH restores transcriptional activity. TFIIH is required for productive but not abortive rDNA transcription, implying a postinitiation role in transcription. The results provide a molecular link between RNA polymerase I transcription andtranscription-coupled repair of active ribosomal RNA genes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/IAA5039202" target="_blank" >IAA5039202: Molecular anatomy of structures directing nuclear compartmentalization</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2002

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cell

  • ISSN

    0092-8674

  • e-ISSN

  • Volume of the periodical

    109

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    297-306

  • UT code for WoS article

    000175412100006

  • EID of the result in the Scopus database