TFIIH plays an essential role in RNA polymerase I transcription
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003591" target="_blank" >RIV/00216208:11120/02:00003591 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/S0092-8674(02)00729-8" target="_blank" >http://dx.doi.org/10.1016/S0092-8674(02)00729-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0092-8674(02)00729-8" target="_blank" >10.1016/S0092-8674(02)00729-8</a>
Alternative languages
Result language
angličtina
Original language name
TFIIH plays an essential role in RNA polymerase I transcription
Original language description
TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNAsynthesis is impaired in TFIIH ts strains. In a mouse, part of cellular TFIIH is localized within the nucleolus and is associated with subpopulations of both RNA polymerase I and the basal factor TIF-IB. Transcription systems lacking TFIIH are inactiveand exogenous TFIIH restores transcriptional activity. TFIIH is required for productive but not abortive rDNA transcription, implying a postinitiation role in transcription. The results provide a molecular link between RNA polymerase I transcription andtranscription-coupled repair of active ribosomal RNA genes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA5039202" target="_blank" >IAA5039202: Molecular anatomy of structures directing nuclear compartmentalization</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell
ISSN
0092-8674
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
297-306
UT code for WoS article
000175412100006
EID of the result in the Scopus database
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