Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003698" target="_blank" >RIV/00216208:11120/02:00003698 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/sj.ijo.0802072" target="_blank" >http://dx.doi.org/10.1038/sj.ijo.0802072</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/sj.ijo.0802072" target="_blank" >10.1038/sj.ijo.0802072</a>

Result language
angličtina
Original language name
Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men
Original language description
The aim of the study was to investigate whether a long-lasting bout of exercise modifies the lipolytic beta- and anti lipolytiC-alpha(2)-adrenergic effect and the antilipolytic effect of insulin in obese subjects. Biopsies of abdominal subcutaneous adipose tissue were performed before and immediately after 2 h exercise (at 50% of VO2max) on an ergometric bicycle. Nine healthy obese male subjects (mean age 38.0 +/- 3.5y; mean body mass index (BMI) 35.6 +/- 3.9kg/m(2)) were included in the experiment. Thelipolytic responsiveness to adrenaline, isoprenaline (beta-adrenergic agonist), UK-14304 (alpha(2)-adrenergic agonist) and insulin was studied in the isolated fat cell obtained by biopsies of subcutaneous adipose tissue from the peri-umbilical region before and after exercise. After exercise, an increase was observed in spontaneous lipolytic rate, and in the lipolytic effect of isoprenaline, but no modification in the lipolytic action of adrenaline. Antilipolytic effects of UK-14304 and
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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