The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000284" target="_blank" >RIV/00216208:11120/07:00000284 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients
Original language description
Thyroid dysfunction is associated with several abnormalities in intermediary metabolism including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide, however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate the role of thyroid hormones in the regulation of ANPinduced lipolysis as well as in the gene expression of HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B), UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and _2AR (_2-adrenergic receptor) in SCAAT of hyperthyroid and hypothyroid patients. Gene expression in SCAAT was studied in13 hypothyroid and 11 hyperthyroid age matched women before and 2-4 months after the normalisation of their thyroid status. A microdialysis study was performed on a subset of 9 hyperthyroid and 10 hypothyroid subjects. ANP- and isoprenali
Czech name
Atriálním natriuretickým peptidem a katecholaminy indukovná lipolýza a genová exprese souvisejících genů v podkožní tukové tkáni u pacientlů s hypo a hyperthyreózou
Czech description
Cílem studie bylo studovat úlohu thyroideálních hormonů na regulaci lipolýzy indukované ANP (atrialní natriuretický peptid) u pacientů s hyper a hypothyreózou, spolu s analýzou genové exprese HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B),UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and 2AR (2-adrenergic receptor)v podkožní tukové tkáni. ANP- a isoprenalinem indukovaná lipolýza byla vyšší u hyperthyroidních pacientů.Genová exprese HSL byla vyšší u hyperthyroidních než u hypothyroidních subjektů. Závěr: thyroidní hormony se účastní regulace ANP- and isoprenalinem-indukované lipolýzy v lidské podkožní tukové tkáni
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology - Endocrinology and Metabolism
ISSN
0193-1849
e-ISSN
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Volume of the periodical
293
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"E246"-"E251"
UT code for WoS article
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EID of the result in the Scopus database
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