Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003123" target="_blank" >RIV/00216208:11120/02:00003123 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/sj/ijo/0801845" target="_blank" >http://dx.doi.org/10.1038/sj/ijo/0801845</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/sj/ijo/0801845" target="_blank" >10.1038/sj/ijo/0801845</a>

Result language
angličtina
Original language name
Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women
Original language description
We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or CAMP. The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mug/m(2) min for 60 min). CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol- and NP-induced lipolysis increase during LCD, in obese women. These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, Lv. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—

Project
<a href="/en/project/NB4674" target="_blank" >NB4674: Metabolism of adipose tissue examined by methods of molecular biology in obese subjects from regions with different risk of cardiovascular diseases.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)