Motor cortex stimulation in rats with chronic constriction injury

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000797" target="_blank" >RIV/00216208:11120/08:00000797 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Motor cortex stimulation in rats with chronic constriction injury

Original language description

Motor cortex stimulation (MCS) has gained a significant role in treatment of neuropathic pain. In order to evaluate effect of MCS in experimental animals we applied MCS to rats with neuropathic pain, which was evoked by chronic constriction injury (CCI)to the left sciatic nerve. Pain thresholds of both hind limbs were measured before, immediately after MCS, 1 h after MCS and 1 day after MCS. Effect of the stimulation was studied with respect to laterality (contralateral and ipsilateral MCS) and duration (short-term 10-min and long-term 1-h stimulation). It was found out that in control rats MCS did not affect thermal nociceptive thresholds. However, in CCI animals following results were obtained: difference score (difference in paw withdrawal latencybetween ligated and non-ligated hind limb) significantly decreased after both short- and long-term contralateral MCS; the difference score after the long-term ipsilateral MCS (related to the ligated hind limb) was not significantly differ

Czech name

Elektricka stimulace mozkove kůry u potkanů s chronickou konstrikcí sedacího nervu

Czech description

U modelu neuropatické bolesti jsme prokázali antinocicepční účinek elektrické stimulace jak kontralaterální, tak ipsilaterální motorické mozkové kůry.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/LC554" target="_blank" >LC554: Neuroscience Centre</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Brain Research

ISSN

0014-4819

e-ISSN

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Volume of the periodical

185

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

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UT code for WoS article

000252942700016

EID of the result in the Scopus database

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