Skin temperature contribution to the decrease in withdrawal latency following chronic constriction injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920437" target="_blank" >RIV/00216208:11120/20:43920437 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.physbeh.2020.113147" target="_blank" >https://doi.org/10.1016/j.physbeh.2020.113147</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.physbeh.2020.113147" target="_blank" >10.1016/j.physbeh.2020.113147</a>
Alternative languages
Result language
angličtina
Original language name
Skin temperature contribution to the decrease in withdrawal latency following chronic constriction injury
Original language description
BACKGROUND: Chronic constriction injury (CCI) is widely used as an animal neuropathic pain model. Neuropathic pain is considered to exist when withdrawal latency to thermal stimulation is decreased after inducing a CCI to the sciatic nerve. However, it is known that CCI leads to changes in skin temperature and that skin temperature can affect withdrawal latency. Aim of this study was to compare withdrawal latencies of constricted and contralateral hind limbs, to thermal stimulation, at the same artificially-induced skin temperatures. METHODS: Neuropathic pain was induced by four ligatures on the left sciatic nerve in adult male Wistar rats. Withdrawal latencies were measured from the 11th to 14th day after ligation, in different ambient temperatures, using the plantar test (Hargreaves method). By changing ambient we produced different hind limb skin temperatures. RESULTS: Our results show that (1) CCI cause an increase in skin temperature; (2) the withdrawal latency was inversely related to ambient and skin temperature in the same manner for both the ligated and contralateral hind limbs; and (3) withdrawal latencies did not differ significantly for the ligated and contralateral hind limbs when the temperature of the hind limbs was artificially made the same (i.e., by changing the ambient temperature). CONCLUSIONS: Withdrawal latencies to thermal stimulation did not differ on ligated and contralateral hind limb after CCI to the sciatic nerve if the temperature of the hind limbs was artificially or mathematically made the same. This finding may have significant impact on the interpretation results of neuropathic pain research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiology & Behavior
ISSN
0031-9384
e-ISSN
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Volume of the periodical
227
Issue of the periodical within the volume
December
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"Article 113147"
UT code for WoS article
000588306800017
EID of the result in the Scopus database
2-s2.0-85089916436