Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002397" target="_blank" >RIV/00216208:11120/11:00002397 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/11:#0000200
Result on the web
<a href="http://dx.doi.org/10.1007/s00125-010-2014-3" target="_blank" >http://dx.doi.org/10.1007/s00125-010-2014-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00125-010-2014-3" target="_blank" >10.1007/s00125-010-2014-3</a>
Alternative languages
Result language
angličtina
Original language name
Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat
Original language description
Our goal was to identify a set of human adipose tissue macrophage (ATM)-specific markers and investigate whether their gene expression in subcutaneous adipose tissue (SAT) as well as in visceral adipose tissue (VAT) is related to obesity and to the occurrence of the metabolic syndrome. ATM-specific markers were identified by DNA microarray analysis of adipose tissue cell types isolated from SAT of lean and obese individuals. We then analysed gene expression of these markers by reverse transcription quantitative PCR in paired samples of SAT and VAT from 53 women stratified into four groups (lean, overweight, obese and obese with the metabolic syndrome). Anthropometric measurements, euglycaemic-hyperinsulinaemic clamp, blood analysis and computed tomography scans were performed. A panel of 24 genes was selected as ATM-specific markers based on overexpression in ATM compared with other adipose tissue cell types. In SAT and VAT, gene expression of ATM markers was lowest in lean and highest
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetologia
ISSN
0012-186X
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
876-887
UT code for WoS article
000288217200022
EID of the result in the Scopus database
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