Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43915727" target="_blank" >RIV/00216208:11120/18:43915727 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/18:N0000031
Result on the web
<a href="https://doi.org/10.1038/ijo.2017.260" target="_blank" >https://doi.org/10.1038/ijo.2017.260</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ijo.2017.260" target="_blank" >10.1038/ijo.2017.260</a>
Alternative languages
Result language
angličtina
Original language name
Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese
Original language description
BACKGROUND/OBJECTIVES: OxLDL-β2GPI complex has been suggested to play a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL-β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development. SUBJECTS/METHODS: Two cohorts of subjects were examined in the study. Cohort I: 36 women with wide range of BMI (17-48 kg/m(2)) and metabolic status (with or without metabolic syndrome (MS); Cohort II: 20 obese women undergoing a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Serum levels of oxLDL-β2GPI were measured by ELISA. Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp and HOMA-IR. mRNA expression of macrophage markers was determined in both subcutaneous (SAT) and visceral (VAT) adipose tissue in Cohort I and in SAT in Cohort II. RESULTS: Serum oxLDL- β2GPI levels were increased in obese subjects with MS compared to lean or obese without MS (obese with MS: 26.6+-5.0 vs lean: 15.17+-1.97, P<0.001; vs obese without MS: 16.36+-2.89, P<0.05). Serum oxLDL-β2GPI correlated with MS indices (glucose, HDL, TG, ureic acid) and with mRNA expression of macrophage markers in VAT. Weight-reducing dietary intervention decreased serum oxLDL-β2GPI levels together with lipid parameters and the mRNA expression of inflammatory markers in SAT. CONCLUSION: OxLDL-β2GPI seems to be an important marker of visceral adipose tissue inflammation and possibly a factor contributing to insulin resistance and metabolic syndrome development in obese patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/GA16-14048S" target="_blank" >GA16-14048S: Limited adipose tissue expandability as a risk factor for development of type 2 diabetes: the role of preadipocytes (LIMEX)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Obesity
ISSN
0307-0565
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
405-411
UT code for WoS article
000428844600017
EID of the result in the Scopus database
2-s2.0-85044578697