Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908016" target="_blank" >RIV/00216208:11120/14:43908016 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2013-3348" target="_blank" >http://dx.doi.org/10.1210/jc.2013-3348</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2013-3348" target="_blank" >10.1210/jc.2013-3348</a>

Result language
angličtina
Original language name
Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction
Original language description
Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examinedin the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels o
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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