Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002396" target="_blank" >RIV/00216208:11120/11:00002396 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2010-1575" target="_blank" >http://dx.doi.org/10.1210/jc.2010-1575</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2010-1575" target="_blank" >10.1210/jc.2010-1575</a>

Result language
angličtina
Original language name
Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: Decreased metabolism and increased immune response
Original language description
It is not known whether biological differences reported between sc adipose tissue (SAT) and visceral adipose tissue (VAT) depots underlie the pathogenicity of visceral fat. We compared SAT and VAT gene expression according to obesity, visceral fat accumulation, insulin resistance, and presence of the metabolic syndrome. Subjects were assigned into four groups (lean, overweight, obese, and obese with metabolic syndrome). Subjects were recruited at a university hospital. Thirty-two women were included. Anthropometric measurements, euglycemic-hyperinsulinemic clamps, blood analyses, and computed tomography scans were performed, and paired samples of SAT and VAT were obtained for DNA microarray-based gene expression profiling. Considering the two fat depots together, 1125 genes were more and 1025 genes were less expressed in lean compared with metabolic syndrome subjects. Functional annotation clustering showed, from lean to metabolic syndrome subjects, progressive down-regulation of metab
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NS10519" target="_blank" >NS10519: Relative abundance of macrophages and other cell populations in adipose tissue in relation to obesity and associated metabolic complications</a><br>
Continuities
R - Projekt Ramcoveho programu EK

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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