The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43905458" target="_blank" >RIV/00216208:11120/12:43905458 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ijo.2011.223" target="_blank" >http://dx.doi.org/10.1038/ijo.2011.223</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ijo.2011.223" target="_blank" >10.1038/ijo.2011.223</a>
Alternative languages
Result language
angličtina
Original language name
The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue
Original language description
Hypoadiponectinemia observed in obesity is associated with insulin resistance, diabetes and atherosclerosis. The aim of the present study was to investigate secretion of adiponectin and its multimeric isoforms by explants derived from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese and non-obese subjects.Design:Paired samples of SAT and VAT and blood samples were obtained from 23 subjects (10 non-obese and 13 obese) undergoing elective abdominal surgery. Total adiponectin quantities and adiponectin isoforms were measured in conditioned media of explants derived from SAT and VAT using enzyme-linked immunosorbent assay and non-denaturing western blot, respectively.Results:Total adiponectin plasma levels were lower in obese than in non-obese subjects (P<0.05). Secretion of total adiponectin in adipose tissue (AT) explants was lower in obese than in non-obese subjects in SAT (P<0.05) but not in VAT. In both, SAT and VAT, the most abundant isoform released into
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Obesity
ISSN
0307-0565
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
1360-1365
UT code for WoS article
000309649400017
EID of the result in the Scopus database
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