Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002944" target="_blank" >RIV/00216208:11120/11:00002944 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/11:00002739 RIV/00023752:_____/11:00001162

Result on the web

<a href="http://dx.doi.org/10.1016/j.neulet.2011.02.024" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2011.02.024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2011.02.024" target="_blank" >10.1016/j.neulet.2011.02.024</a>

Result language

angličtina

Original language name

Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients

Original language description

FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure ofstructures relevant to normal language processing. To investigate the potential link between grey matter concentration (GMC) changes in patients with schizophrenia and the FOXP2 rs2396753 polymorphism previously reported to be associated with hallucinations in schizophrenia, we analysed high-resolution anatomical magnetic resonance images of 40 genotyped patients with schizophrenia and 36 healthy controls, using optimised voxel-based morphometry (VBM). Here we show that the common SNP rs2396753 (C > A)gene variant of the FOXP2 gene has significant effects on GMC in patients with schizophrenia, within regions of the brain known to be affected by this disease. Our data suggest that GMC reductions in schizophrenia may be driven by C alle

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/1M0517" target="_blank" >1M0517: Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Volume of the periodical

493

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

131-135

UT code for WoS article

000289582100016

EID of the result in the Scopus database

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