Association between alpha-2-adrenergic receptor polymorphism and schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00080556" target="_blank" >RIV/00216224:14310/12:00080556 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Association between alpha-2-adrenergic receptor polymorphism and schizophrenia
Original language description
The important role of adrenergic system in psychiatric disorder such as depression and schizophrenia has been proved. Alpha-2-adrenergic receptor plays a key role in regulation of neurotransmitter releasing from sympathetic nerves and adrenergic neuronsand have been implicated in mediating antipsychotic response. Further the role of alpha-2-adrenergic receptor in pathophysiology of schizophrenia is supported by the fact that many of the successful antipsychotics demonstrate affinity to these receptors.In this study we investigated -1291 C/G polymorphism in the promoter region of alpha-2-adrenergic receptor candidate gene. We focused to regulatory region of candidate gene because schizophrenia might be a chronic disease and there is a suggestion thatregulatory regions of genes may be particularly relevant to chronic diseases.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP309%2F09%2FP361" target="_blank" >GP309/09/P361: Relationship of candidate genes polymorphisms interaction to pathogenesis of schizophrenia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů