GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072067" target="_blank" >RIV/00216224:14740/13:00072067 - isvavai.cz</a>
Result on the web
<a href="http://www.biologydirect.com/content/8/1/5" target="_blank" >http://www.biologydirect.com/content/8/1/5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1745-6150-8-5" target="_blank" >10.1186/1745-6150-8-5</a>

Result language
angličtina
Original language name
GABBR1 has a HERV-W LTR in its regulatory region - a possible implication for schizophrenia
Original language description
Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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