Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43899314" target="_blank" >RIV/00216208:11120/12:43899314 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/12:43913798

Result on the web

<a href="http://dx.doi.org/10.1503/jpn.110143" target="_blank" >http://dx.doi.org/10.1503/jpn.110143</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1503/jpn.110143" target="_blank" >10.1503/jpn.110143</a>

Result language

angličtina

Original language name

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

Original language description

Smaller hippocampal volumes relative to controls are among the most replicated neuroimaging findings in individuals with unipolar but not bipolar depression. Preserved hippocampal volumes in most studies of participants with bipolar disorder may reflectpotential neuroprotective effects of lithium (Li). Methods: To investigate hippocampal volumes in patients with bipolar disorder while controlling for Li exposure, we performed a meta-analysis of neuroimaging studies that subdivided patients based on thepresence or absence of current Li treatment. To achieve the best coverage of literature, we categorized studies based on whether all or a majority, or whether no or a minority of patients were treated with Li. Hippocampal volumes were compared by combining standardized differences between means (Cohen d) from individual studies using random-effects models. Conclusion: When expos ure to Li was minimized, patients with bipolar disorder showed smaller hippocampal volumes than controls or L

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Psychiatry & Neuroscience

ISSN

1180-4882

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

5

Country of publishing house

CA - CANADA

Number of pages

11

Pages from-to

333-343

UT code for WoS article

000309209800007

EID of the result in the Scopus database

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