Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43896089" target="_blank" >RIV/00216208:11120/12:43896089 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/12:43913771

Result on the web

<a href="http://dx.doi.org/10.1111/j.1399-5618.2012.01013.x" target="_blank" >http://dx.doi.org/10.1111/j.1399-5618.2012.01013.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1399-5618.2012.01013.x" target="_blank" >10.1111/j.1399-5618.2012.01013.x</a>

Result language

angličtina

Original language name

Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment

Original language description

Hippocampal volume decrease associated with illness burden is among the most replicated findings in unipolar depression. The absence of hippocampal volume changes in most studies of individuals with bipolar disorder (BD) may reflect neuroprotective effects of lithium (Li). Methods: We recruited 17 BD patients from specialized Li clinics, with at least two years of regularly monitored Li treatment (Li group), and compared them to 12 BD participants with < 3 months of lifetime Li exposure and no Li treatment within two years prior to the scanning (non-Li group) and 11 healthy controls. All BD patients had at least 10 years of illness and five episodes. We also recruited 13 Li-na?ve, young BD participants (15-30 years of age) and 18 sex- and age-matched healthy controls. We compared hippocampal volumes obtained from 1.5-T magnetic resonance imaging (MRI) scans using optimized voxel-based morphometry with small volume correction. Results: The non-Li group had smaller left hippocampal volum

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bipolar Disorders

ISSN

1398-5647

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

261-270

UT code for WoS article

000303438000005

EID of the result in the Scopus database

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