Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908343" target="_blank" >RIV/00216208:11120/14:43908343 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/14:43914538
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response
Original language description
Neuroimaging studies have demonstrated an association between lithium (Li) treatment and brain structure in human subjects. A crucial unresolved question is whether this association reflects direct neurochemical effects of Li or indirect effects secondary to treatment or prevention of episodes of bipolar disorder (BD). To address this knowledge gap, we compared manually traced hippocampal volumes in 37 BD patients with at least 2 years of Li treatment (Li group), 19 BD patients with <3 months of lifetime Li exposure over 2 years ago (non-Li group) and 50 healthy controls. All BD participants were followed prospectively and had at least 10 years of illness and a minimum of five episodes. We established illness course and long-term treatment response toLi using National Institute of Mental Health (NIMH) life charts. Results The non-Li group had smaller hippocampal volumes than the controls or the Li group (F-2,F-102=4.97, p=0.009). However, the time spent in a mood episode on the curren
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
AN - Psychology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychological Medicine
ISSN
0033-2917
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
507-517
UT code for WoS article
000330592300006
EID of the result in the Scopus database
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