Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906698" target="_blank" >RIV/00216208:11120/12:43906698 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/12:43913778

Result on the web

<a href="http://dx.doi.org/10.1503/jpn.110097" target="_blank" >http://dx.doi.org/10.1503/jpn.110097</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1503/jpn.110097" target="_blank" >10.1503/jpn.110097</a>

Result language

angličtina

Original language name

Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study

Original language description

Neuroprotective effects of lithium (Li) have been well documented in tissue cultures and animal models, whereas human data continue to be limited. Previous studies investigating the association between Li treatment and brain N-acetylaspartate (NAA), a putative neuronal marker, showed mixed results because of methodological heterogeneity. Methods: To investigate the effects of Li on prefrontal cortex NAA levels, we compared patients with bipolar disorder from specialized Li clinics in Berlin and Halifaxwith at least 2 years of ongoing Li treatment (Li group), patients with lifetime Li exposure of less than 3 months more than 2 years ago (non-Li group) and healthy controls. Participants in both patient groups had at least 10 years of illness and 5 episodes. We measured left prefrontal NAA levels using 1.5-T magnetic resonance spectroscopy. Conclusion: Whereas patients with bipolar disorder, substantial illness burden and limited lifetime Li exposure had significantly lower prefrontal NA

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Psychiatry & Neuroscience

ISSN

1180-4882

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

3

Country of publishing house

CA - CANADA

Number of pages

8

Pages from-to

185-192

UT code for WoS article

000303945300004

EID of the result in the Scopus database

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