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Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43902673" target="_blank" >RIV/00216208:11120/12:43902673 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14740/12:00063476 RIV/00064173:_____/12:43902673

  • Result on the web

    <a href="http://dx.doi.org/10.1186/1471-2202-13-57" target="_blank" >http://dx.doi.org/10.1186/1471-2202-13-57</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/1471-2202-13-57" target="_blank" >10.1186/1471-2202-13-57</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy

  • Original language description

    Vascular endothelial growth factor (VEGF) is not only a potent angiogenic factor but it also promotes axonal outgrowth and proliferation of Schwann cells. The aim of the present study was to quantitatively assess reinnervation of musculocutaneous nerve (MCN) stumps using motor and primary sensory neurons after plasmid phVEGF transfection and end-to-end (ETE) or end-to-side (ETS) neurorrhaphy. The distal stump of rat transected MCN, was transfected with plasmid phVEGF, plasmid alone or treated with vehiculum and reinnervated following ETE or ETS neurorrhaphy for 2 months. The number of motor and dorsal root ganglia neurons reinnervating the MCN stump was estimated following their retrograde labeling with Fluoro-Ruby and Fluoro-Emerald. Reinnervation ofthe MCN stumps was assessed based on density, diameter and myelin sheath thickness of regenerated axons, grooming test and the wet weight index of the biceps brachii muscles. Results: Immunohistochemical detection under the same condition

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BMC Neuroscience

  • ISSN

    1471-2202

  • e-ISSN

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    Art. Nr. 57

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    1-11

  • UT code for WoS article

    000308692500001

  • EID of the result in the Scopus database