Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43902673" target="_blank" >RIV/00216208:11120/12:43902673 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00063476 RIV/00064173:_____/12:43902673
Result on the web
<a href="http://dx.doi.org/10.1186/1471-2202-13-57" target="_blank" >http://dx.doi.org/10.1186/1471-2202-13-57</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1471-2202-13-57" target="_blank" >10.1186/1471-2202-13-57</a>
Alternative languages
Result language
angličtina
Original language name
Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy
Original language description
Vascular endothelial growth factor (VEGF) is not only a potent angiogenic factor but it also promotes axonal outgrowth and proliferation of Schwann cells. The aim of the present study was to quantitatively assess reinnervation of musculocutaneous nerve (MCN) stumps using motor and primary sensory neurons after plasmid phVEGF transfection and end-to-end (ETE) or end-to-side (ETS) neurorrhaphy. The distal stump of rat transected MCN, was transfected with plasmid phVEGF, plasmid alone or treated with vehiculum and reinnervated following ETE or ETS neurorrhaphy for 2 months. The number of motor and dorsal root ganglia neurons reinnervating the MCN stump was estimated following their retrograde labeling with Fluoro-Ruby and Fluoro-Emerald. Reinnervation ofthe MCN stumps was assessed based on density, diameter and myelin sheath thickness of regenerated axons, grooming test and the wet weight index of the biceps brachii muscles. Results: Immunohistochemical detection under the same condition
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Neuroscience
ISSN
1471-2202
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
Art. Nr. 57
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1-11
UT code for WoS article
000308692500001
EID of the result in the Scopus database
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