Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43903261" target="_blank" >RIV/00216208:11120/12:43903261 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/s11535-012-0003-x" target="_blank" >http://dx.doi.org/10.2478/s11535-012-0003-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11535-012-0003-x" target="_blank" >10.2478/s11535-012-0003-x</a>

Result language
angličtina
Original language name
Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy
Original language description
A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabeticnephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (-786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-co
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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