Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010158" target="_blank" >RIV/00216224:14110/04:00010158 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes

Original language description

Background and aims: Set association of selected genetic polymorphisms (40 single nucleotide polymorphisms (SNPs)) in 26 candidate genes on chromosomes 1, 3, 4, 6, 7, 12, 16, 17, 19, 20 and 22 with diabetic nephropathy (DN) was studied in patients with type 2 diabetes mellitus. Products of genes studied were components of renin-angiotensin system, other haemodynamic factors, antioxidant enzymes, cytokines and growth factors, AGE-receptors, extracellular matrix remodelation enzymes and others. Materialsand methods: A total of 650 unrelated Caucasian subjects were enrolled into study comprising three groups: diabetics with parallel DN (cases), diabetics without DN (controls 1) and non-diabetics (controls 2). DN diagnosis was based on assessment of albumin excretion rate (AER). Genotypes were detected by means of PCR-based methodology. Set association study was performed to find SNPs jointly associated with disease. Results: An initial comparison of genotype frequencies in case and poole

Czech name

Multilokusovy pristup k identifikaci genetickych rizikovych faktoru diabeticke nefropatie u diabetu 2. typu

Czech description

Predbezne vysledky naznacuji, ze vybrane polymorfizmy v genech kodujicich AGE-receptory, antioxidacni enzymy a cytokiny funguji jako rizikove faktory diabeticke nefropatie.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/GP303%2F02%2FD127" target="_blank" >GP303/02/D127: Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetologia

ISSN

0012-186X

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

Suppl 1

Country of publishing house

DE - GERMANY

Number of pages

1

Pages from-to

49

UT code for WoS article

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EID of the result in the Scopus database

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