Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906592" target="_blank" >RIV/00216208:11120/12:43906592 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/12:43913773

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls

Original language description

Background: Inflammatory immune processes have been clearly implicated in the etiopathology of schizophrenia. There are, however, only limited data dealing with immune parameters in the first episode patients with schizophrenia and the course of these parameters during treatment. Subjects and Methods: The presented study compared plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-alpha in 25 patients with the first episode of schizophrenia with the minimal exposition of antipsychotics before and after treatment and with age and sex matched group of healthy volunteers. Changes in plasma cytokine levels were investigated after 4 weeks of treatment in relationship with the therapeutic outcome. Results: Our results show significantly increased plasmalevels of IL-6 (p <= 0.001) and TNF-alpha (p <= 0.001) in patients at the admission in comparison with healthy volunteers. After 4 weeks of the treatment the PANSS score decreased (p <= 0.001), concurrently the plasma level of IL-6 decre

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NT13843" target="_blank" >NT13843: The influence of immune system dysregulation and latent toxoplasmosis on brain morphology in schizophrenia: animal models and a prospective volumetric study in patients</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatria Danubina

ISSN

0353-5053

e-ISSN

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Volume of the periodical

24

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

HR - CROATIA

Number of pages

4

Pages from-to

"S153"-"S156"

UT code for WoS article

000309094600035

EID of the result in the Scopus database

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