Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4 bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906765" target="_blank" >RIV/00216208:11120/13:43906765 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/13:00392579 RIV/00023752:_____/13:43914167 RIV/00216208:11110/13:00011958 RIV/00064165:_____/13:00011958

Result on the web

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >http://dx.doi.org/10.1007/s00213-012-2797-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >10.1007/s00213-012-2797-7</a>

Result language

angličtina

Original language name

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4 bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Original language description

Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. MATERIALS AND METHODS: Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamineand its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. RESULTS: 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychopharmacology

ISSN

0033-3158

e-ISSN

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Volume of the periodical

225

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

19

Pages from-to

75-93

UT code for WoS article

000313163900007

EID of the result in the Scopus database

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